Mouse Genome Informatics
ht
    Rps6ka3tm1.1Kry/Rps6ka3+
involves: 129X1/SvJ
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• no defects detected by histological analysis of the heart or the aorta

craniofacial
• widened due to reduced cranial bones
• reduced size observed at E16 and at birth
• reduced size observed at E16 and at birth
• reduced size observed at E16 and at birth

digestive/alimentary system
N
• no defects detected by histological analysis of the esophagus, stomach, duodenum, ileum, or colon

endocrine/exocrine glands
N
• no defects detected by histological analysis of the salivary, mammary, pancreas, pituitary, thyroid, or adrenal glands
• no defects detected by histological analysis of the bone marrow

hearing/vestibular/ear
N
• no defects detected by histological analysis of the ear

hematopoietic system
N
• no defects detected by histological analysis of the bone marrow

immune system
N
• no defects detected by histological analysis of the thymus, spleen, or lymph nodes

liver/biliary system
N
• no defects detected by histological analysis of the liver

muscle
N
• no defects detected by histological analysis of striated muscle

renal/urinary system
N
• no defects detected by histological analysis of the kidney or urinary bladder

reproductive system
N
• no defects detected by histological analysis of the testis, epididymis, vas deferens, prostate, or seminal or accessory glands

respiratory system
N
• no defects detected by histological analysis of the nose, trachea, lung, or pleura

skeleton
• widened due to reduced cranial bones
• reduced size observed at E16 and at birth
• reduced size observed at E16 and at birth
• reduced size observed at E16 and at birth
• reduced long bone length at 1 month of age
• marked reduction in bone mass of long bones at 1 and 2 months of age
• marked reduction in bone mass of vertebrae at 1 and 2 months of age
• marked reduction in bone mass of long bones at 1 and 2 months of age
• decreased bone formation rate, indicative of impaired osteoblast function
• normal number and function of osteoclasts
• delay of skull mineralization observed at E16 and at birth

taste/olfaction
N
• no defects detected by histological analysis of the olfactory mucosa and tongue

vision/eye
N
• no defects detected by histological analysis of the eye

nervous system
N
• no defects detected by histological analysis of the cerebral cortex, hippocampus, basal ganglia, cerebellum, or brain stem

integument
N
• no defects detected by histological analysis of the skin

Mouse Models of Human Disease
OMIM IDRef(s)
Coffin-Lowry Syndrome; CLS 303600 J:89403