Phenotypes for Gdnf Slit2 MGI:3043170 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gdnf^tm1Rosl/Gdnf⁺ Slit2^tm1Matl/Slit2^tm1Matl
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdnf^tm1Rosl mutation (0 available); any Gdnf mutation (20 available)
Slit2^tm1Matl mutation (2 available); any Slit2 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal ureter morphology ( J:90324 )

• at E14.5 in 6/30 kidneys 2 ureters or 1 ureter and a blind-ending ectopic protusion are found, in 24/30 only a single ureter is found demonstrating a partial rescue of the Slit2^tm1Matl homozygous phenotype

• in 5/15 kidneys with a single ureter, the single ureter did not undergo remodeling and remained connected to the nephric duct, in the other 10/15 ureter remodeling was also rescued with the ureter connected to the bladder

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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