Phenotypes Associated with This Genotype

Genotype
MGI:3042845

• Allelic Composition: Ckb^tm1Bew/Ckb^tm1Bew
• Genetic Background: involves: 129P/Ola * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased susceptibility to pharmacologically induced seizures ( J:89399 )

• homozygous mutants need significantly more pentylenetetrazole to induce seizures

• homozygous mutants display more preseizure myoclonic jerks compared to wild-type mice

increased exploration in new environment ( J:89399 )

• homozygous mutants are more active 20 and 30 minutes into an open-field test compared to wild-type mice

• in the open-field test, homozygotes remain hyperactive with little sitting and grooming, and none of them exhibit the formation of a home base, suggesting diminished habituation

abnormal spatial learning ( J:89399 )

• homozygous mutants take longer to find a submerged platform compared to wild-type mice

nervous system

decreased susceptibility to pharmacologically induced seizures ( J:89399 )

• homozygous mutants need significantly more pentylenetetrazole to induce seizures

• homozygous mutants display more preseizure myoclonic jerks compared to wild-type mice

abnormal hippocampal mossy fiber morphology ( J:89399 )

• the intra- and infrapyramidal mossy fiber area is enlarged in homozygous mutants compared to wild-type mice