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Phenotypes Associated with This Genotype
Genotype
MGI:3042275
Allelic
Composition
Amhr2tm3(cre)Bhr/Amhr2+
Fsttm1Zuk/Fsttm2Zuk
Genetic
Background
involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2tm3(cre)Bhr mutation (1 available); any Amhr2 mutation (22 available)
Fsttm1Zuk mutation (2 available); any Fst mutation (13 available)
Fsttm2Zuk mutation (1 available); any Fst mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• the majority of ovaries in 8 month old mice appeared hemorrhagic
• ovaries were histologically normal through 21 days of age
• defects became apparent after 3 months of age
• some mice developed Sertoli cell tubule-like structures, reminiscent of the ovarian tumors observed in mice inhibin-deficient mice, mice overexpressing follistatin and follicle stimulating hormone, mice lacking both estrogen receptors alpha and beta, and mice overexpressing anti-Mullerian hormone
• decreased numbers of antral follicles
• observed in 2 mice

homeostasis/metabolism
N
• circulating estradiol levels did not differ from those of controls

reproductive system
N
• male mice were fertile
• the majority of ovaries in 8 month old mice appeared hemorrhagic
• ovaries were histologically normal through 21 days of age
• defects became apparent after 3 months of age
• some mice developed Sertoli cell tubule-like structures, reminiscent of the ovarian tumors observed in mice inhibin-deficient mice, mice overexpressing follistatin and follicle stimulating hormone, mice lacking both estrogen receptors alpha and beta, and mice overexpressing anti-Mullerian hormone
• decreased numbers of antral follicles
• observed in 2 mice
• impaired ovulation in response to human chorionic gonadotropin (hCG)
• impaired only in mature adult mice (6 months of age), ovulation was normal in 3 week old mice
• of 11 female experimental mice, 1 was completely infertile
• of 11 female experimental mice, 10 showed reduced fertility, yielding reduced litter number and size
• impaired only in mature adult mice (6 months of age), fertilization was normal in 3 week old mice

cardiovascular system
• the majority of ovaries in 8 month old mice appeared hemorrhagic


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory