Phenotypes Associated with This Genotype

Genotype
MGI:3042231

• Allelic Composition: Nr2f2^tm1Tsa/Nr2f2^tm1Tsa
• Genetic Background: either: 129S7/SvEvBrd or C57BL/6 or (involves: 129S7/SvEvBrd * C57BL/6 * ICR)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:54469 )

• homozygous null embryos died around E10 probably as a result of hemorrhage and edema in the heart and brain

cardiovascular system

decreased angiogenesis ( J:54469 )

• at E9, immunological and molecular analyses of the vascular system revealed a reduction in the extent and complexity of microvasculature in the head and spine regions, suggesting impaired angiogenesis and vascular remodeling

• angiogenic defects were consistent with a loss of function in the mesenchymal compartments of the head, spine, and heart

abnormal vein morphology ( J:54469 )

• by E9-E9.5, both anterior and posterior cardinal veins appeared either malformed or had collapsed

abnormal anterior cardinal vein morphology ( J:54469 )

• by E9-E9.5, anterior cardinal vein appeared either malformed or collapsed

abnormal posterior cardinal vein morphology ( J:54469 )

• by E9-E9.5, posterior cardinal vein appeared either malformed or collapsed

absent trabeculae carneae ( J:54469 )

• at E9.5, some mutant embryos displayed a reduced trabeculation

abnormal heart tube morphology ( J:54469 )

• at E9.5, wild-type hearts displayed an enlarged common atrial chamber, whereas mutant hearts showed only a primitive atrial tube situated on the left

• the primitive atrial tube was connected to a small and primitive sinus venosus situated over the midline; as a result, the mutant pericardial-peritoneal cavity was empty

hemorrhage ( J:54469 )

• at E9.5, homozygous null mice displayed hemorrhage in the frontonasal process and edematous cysts on the brain

• at E10-E10.5, mutant embryos displayed blood-filled brain vesicles and hemorrhagic hearts

embryo

embryo phenotype ( J:120852 )

N • placentas of homozygous mutant embryos developed normally

incomplete somite formation ( J:54469 )

• at E10-E10.5, partially resorbed embryos contained less than 29 somites versus 30-35 somites typically observed in wild-type embryos

muscle

absent trabeculae carneae ( J:54469 )

• at E9.5, some mutant embryos displayed a reduced trabeculation