Phenotypes Associated with This Genotype

Genotype
MGI:3042041

• Allelic Composition: Mapk7^tm1Jdl/Mapk7^tm1Jdl; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:89215 )

• adult mice developed a wasting syndrome and died 2 to 4 weeks after induction of cre recombinase

behavior/neurological

head tilt ( J:89215 )

• approximately 30% displayed head tilting and hemiparesis

cardiovascular system

abnormal blood vessel morphology ( J:89215 )

• the endothelial cells lining the blood vessels became round, irregularly aligned, and apoptotic

abnormal heart morphology ( J:89215 )

• multifocal cellular plaques containing large round cells observed in the ventricle

myocardial fiber degeneration ( J:89215 )

• diffused degeneration of myocardial fibers was observed along with multifocal inflammatory changes

hemorrhage ( J:89215 )

• multifocal acute hemorrhages in multiple organs including the heart, brain, and lung

• associated with abnormal endothelial cells

abnormal vascular permeability ( J:89215 )

• blood vessels became abnormally leaky

cellular

abnormal apoptosis ( J:89215 )

• apoptosis of endothelial cells leading to increased vascular permeability and hemorrage

growth/size/body

cachexia ( J:89215 )

muscle

myocardial fiber degeneration ( J:89215 )

• diffused degeneration of myocardial fibers was observed along with multifocal inflammatory changes