Phenotypes for Prdm2 Trp53 MGI:3041266 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Prdm2^tm1Shg/Prdm2^tm1Shg Trp53^tm1Tyj/Trp53⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm2^tm1Shg mutation (1 available); any Prdm2 mutation (99 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:71406 )

• mean age of survival was 415 days vs. mice heterozygous for Trp53^tm1Tyj alone or homozygous Prdm2^tm1Shg alone, which survived to ~550 days

neoplasm

increased tumor incidence ( J:71406 )

• of types similar to those found in mice homozygous for Prdm2^tm1Shg alone

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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