Phenotypes Associated with This Genotype

Genotype
MGI:3041081

• Allelic Composition: Rps6^tm1Gtho/Rps6^tm1Gtho; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell morphology ( J:62795 )

• mice induced with interferon gamma exhibited similar responses to starvation as controls, although it was noted that 40S ribosomes were absent and 60S ribosomes were increased in number in mutant liver recovering from starvation

abnormal cell cycle ( J:62795 )

• expression of cell cycle markers such as cyclin E and cyclin A were not seen in mutant hepatocytes suggesting a block in cell cycle progression

liver/biliary system

impaired liver regeneration ( J:62795 )

• after partial hepatectomy, mutant liver failed to regenerate after 10 days; histopathology revealed no evidence of regenerative or pathological processes in mutant liver; expression of cell cycle markers such as cyclin E and cyclin A were not seen in mutants suggesting a block in cell cycle progression