Phenotypes Associated with This Genotype

Genotype
MGI:3040878

• Allelic Composition: Klhl10^tm1Zuk/Klhl10⁺
• Genetic Background: chimera involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Disrupted spermatogenesis in Klhl10^tm1Zuk chimeric mice

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:89621 )

♂ • some seminiferous tubules have only Sertoli cells and no gametes

abnormal Sertoli cell morphology ( J:89621 )

♂ • Sertoli cell vacuolation is frequently seen

small testis ( J:89621 )

♂ • males have testes that are smaller compared to wild-type mice

reproductive system

decreased germ cell number ( J:89621 )

• increased apoptosis of germ cells is seen

abnormal seminiferous tubule morphology ( J:89621 )

♂ • some seminiferous tubules have only Sertoli cells and no gametes

abnormal Sertoli cell morphology ( J:89621 )

♂ • Sertoli cell vacuolation is frequently seen

small testis ( J:89621 )

♂ • males have testes that are smaller compared to wild-type mice

abnormal spermiogenesis ( J:89621 )

♂ • asynchronized development of haploid cells is seen

♂ • multinucleated round spermatids are found in the epithelium

arrest of spermatogenesis ( J:89621 )

♂ • spermiogenesis arrests in the elongating stage (stage 9)

♂ • sloughing off of haploid germ cells results in spermatids being found in the epididymis

male infertility ( J:89621 )

♂ • males, including male chimeras, are sterile

cellular

decreased germ cell number ( J:89621 )

• increased apoptosis of germ cells is seen