Klhl10^tm1Zuk
Targeted Allele Detail

Summary

• Symbol: Klhl10^tm1Zuk
• Name: kelch-like 10; targeted mutation 1, Martin M Matzuk
• MGI ID: MGI:3040869
• Gene: Klhl10 Location: Chr11:100332743-100347848 bp, + strand Genetic Position: Chr11, 63.47 cM, cytoband D
• Alliance: Klhl10^tm1Zuk page

Disrupted spermatogenesis in Klhl10^tm1Zuk chimeric mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mouse Generated: Earliest citation of chimera generation: J:89621
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1, containing the start codon, was deleted via homologous recombination. Northern blot analysis showed decreased expression in heterozygous stem cells. (J:89621)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klhl10 Mutation: 16 strains or lines available

Notes

Haploinsufficiency of Klhl10 in male chimeras prevents genetic transmission of the mutated allele from males and increases the difficulty of generating non-chimeric heterozygous mice. Phenotype data reported are from chimeric male mice and a single heterozygous male generated from a female chimera.

References

• Original: J:89621 Yan W, et al., Haploinsufficiency of kelch-like protein homolog 10 causes infertility in male mice. Proc Natl Acad Sci U S A. 2004 May 18;101(20):7793-8
• All: 1 reference(s)