Phenotypes Associated with This Genotype

Genotype
MGI:3040763

• Allelic Composition: Polm^tm1Crey/Polm^tm1Crey
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:75927 )

N • mice exhibit normal hypermutation patterns

abnormal B cell proliferation ( J:85190 )

• maturation of B cells from IgM- to IgM+ is slowed down

• light chain rearrangements are impaired

abnormal Peyer's patch morphology ( J:85190 )

• the separation of T and B cells into separate compartments is absent in Peyer's patches

• underdeveloped B cell compartment in Peyer's patches

decreased B cell number ( J:75927 , J:85190 )

• in half of mice (J:75927)

• marked B cell deficiency in the spleen and Peyer's patches in about 50% of homozygotes (J:85190)

lymphoid hypoplasia ( J:85190 )

• lower cellularity of peripheral lymphoid tissues (spleen and lymph nodes including Peyer's patches)

reproductive system

reproductive system phenotype ( J:75927 )

N • mice exhibit normal fertility

hematopoietic system

abnormal B cell proliferation ( J:85190 )

• maturation of B cells from IgM- to IgM+ is slowed down

• light chain rearrangements are impaired

decreased B cell number ( J:75927 , J:85190 )

• in half of mice (J:75927)

• marked B cell deficiency in the spleen and Peyer's patches in about 50% of homozygotes (J:85190)

cellular

abnormal B cell proliferation ( J:85190 )

• maturation of B cells from IgM- to IgM+ is slowed down

• light chain rearrangements are impaired

digestive/alimentary system

abnormal Peyer's patch morphology ( J:85190 )

• the separation of T and B cells into separate compartments is absent in Peyer's patches

• underdeveloped B cell compartment in Peyer's patches