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Phenotypes Associated with This Genotype
Genotype
MGI:3040651
Allelic
Composition		 Stat3tm1Vpo/Stat3tm2Vpo
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * CBA * BALB/cAn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm1Vpo mutation (0 available); any Stat3 mutation (72 available)
Stat3tm2Vpo mutation (0 available); any Stat3 mutation (72 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:89194 )
• increased TNF and IL-6 production by peritoneal macrophages stimulated by LPS and IFN-gamma, relative to those of wild-type
increased interleukin-6 secretion ( J:89194 )
• increased IL-6 production by peritoneal macrophages stimulated by LPS and IFN-gamma, relative to those of wild-type
increased tumor necrosis factor secretion ( J:89194 )
• increased TNF production by peritoneal macrophages stimulated by LPS and IFN-gamma, relative to those of wild-type

hematopoietic system
abnormal macrophage physiology ( J:89194 )
• increased TNF and IL-6 production by peritoneal macrophages stimulated by LPS and IFN-gamma, relative to those of wild-type

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory