About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3040184
Allelic
Composition
Ticam2tm1Aki/Ticam2tm1Aki
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ticam2tm1Aki mutation (0 available); any Ticam2 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• defects in MyD88-independent TLR4 signaling resulting in impaired splenocyte proliferation and upregulation of surface molecules
• impaired responses to LPS stimulation
• reduced IL-6 production when induced with LPS
• increased susceptibility to SARS-CoV MA15
• greater SARS-CoV induced weight loss than control mice
• pulmonary hemorrhage scores were significantly higher in mutant mice at 4 d postinfection compared to controls
• virus load is significantly higher at day 2 postinfection compared to controls

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Coronavirus infectious disease DOID:0080599 J:270045


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
11/22/2022
MGI 6.22
The Jackson Laboratory