Phenotypes for Nf1 Rasa1 MGI:3040176 MGI Mouse

cardiovascular system

abnormal heart morphology ( J:29825 )

• the heart and surrounding trunk are abnormal

embryo

increased cranial neural crest cell apoptosis ( J:29825 )

• cell death is widespread in migrating cranial neural crest

abnormal embryo turning ( J:29825 )

• embryo turning usually failed

embryonic growth arrest ( J:29825 )

• arrested development around E8.5

abnormal embryonic tissue morphology ( J:29825 )

abnormal pharyngeal arch morphology ( J:29825 )

• lacking or abnormal

absent limb buds ( J:29825 )

abnormal neural tube morphology ( J:29825 )

• localized regions of cell proliferation and outgrowth in the neural tube

failure of somite differentiation ( J:29825 )

• fewer than 8 disorganized somites

abnormal extraembryonic tissue morphology ( J:29825 )

enlarged allantois ( J:29825 )

excessive folding of visceral yolk sac ( J:29825 )

• ruffled yolk sac

hearing/vestibular/ear

absent otic vesicle ( J:29825 )

• otic placodes develop but do not develop into vesicles

nervous system

increased hindbrain apoptosis ( J:29825 )

• cell death was widespread in the hindbrain

abnormal neural tube morphology ( J:29825 )

• localized regions of cell proliferation and outgrowth in the neural tube

abnormal brain morphology ( J:29825 )

absent midbrain ( J:29825 )

• midbrain fails to develop

absent forebrain ( J:29825 )

• failure of forebrain structures to develop

abnormal hindbrain morphology ( J:29825 )

• dorsal surface of the hindbrain failed to close

craniofacial