Phenotypes Associated with This Genotype

Genotype
MGI:3040175

• Allelic Composition: Rasa1^tm1Paw/Rasa1^tm1Paw; Tek^tm1Dmt/Tek^tm1Dmt
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal dorsal aorta morphology ( J:29825 )

• at 16 somite stage, thinning of the dorsal aorta and aberrant ventral arteries seen

absent vitelline blood vessels ( J:29825 )

distended pericardium ( J:29825 )

• heart is surrounded by a distended pericardium by E9.5

hemorrhage ( J:29825 )

• by E9.5, local ruptures in the vasculature and leakage of blood into the body cavity occurred

embryo

absent vitelline blood vessels ( J:29825 )

abnormal visceral yolk sac morphology ( J:29825 )

abnormal vitelline vascular remodeling ( J:29825 )

• endothelial cells failed to reorganize into a vascular network