Phenotypes Associated with This Genotype

Genotype
MGI:3039549

• Allelic Composition: Lfng^tm1Grid/Lfng^tm1Grid
• Genetic Background: involves: 129S1/SvImJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:48810 )

• some neonatal lethality due to respiratory difficulties related to a malformed rib cage

• less severely affected mice survive

embryo

abnormal dorsal-ventral polarity of the somites ( J:48810 )

• defects in somite formation after E8.5

• size and shape are irregular

• metameric pattern is not maintained

skeleton

abnormal thoracic cage morphology ( J:48810 )

abnormal sternocostal joint morphology ( J:88580 )

• number of ribs attached to the sternum is reduced

abnormal costovertebral joint morphology ( J:48810 )

• some ribs are detached from the vertebral column

decreased rib number ( J:88580 )

• reduced number of ribs

rib bifurcation ( J:48810 )

rib fusion ( J:48810 )

abnormal vertebrae morphology ( J:48810 )

• regular metameric pattern of vertebrae is disrupted

decreased cervical vertebrae number ( J:88580 )

• reduced number of cervical vertebrae

nervous system

fused dorsal root ganglion ( J:48810 )

reproductive system

female infertility ( J:48810 , J:105928 )

♀ • some, but not all, females are infertile (J:48810)

♀ • genetic background may contribute to whether or not mice are fertile (J:105928)

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:62727 )

N • at E18, homozygotes display no alterations in cochlear hair cell number or patterning relative to wild-type or heterozygous mice