Mouse Genome Informatics
hm
    Rlbp1tm1Jsa/Rlbp1tm1Jsa
involves: 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
pigmentation
• 3 out of 4 homozygotes were albino

vision/eye
• after being kept in constant light for more than 20 days less loss of photoreceptors occurred than in albino controls
• after 60 days in constant light the number of nuclei in the outer nuclear layer was reduced but still more than 4X that of albino controls
• did not occur in albino mice maintained in a normal light cycle unlike albino controls
• photoreceptor nuclei in the outer nuclear layer remainder normal unlike albino controls where the number is reduced
• regeneration of bleached rhodopsin required 18-24 hours as opposed to a more normal 1.5 hours
• little restoration of dark adaptation occurred in the 3 hours which was adequate for control mice
• cone recovery after bleaching was delayed by a factor of 2 relative to controls

nervous system
• after being kept in constant light for more than 20 days less loss of photoreceptors occurred than in albino controls
• after 60 days in constant light the number of nuclei in the outer nuclear layer was reduced but still more than 4X that of albino controls

integument
• 3 out of 4 homozygotes were albino

Mouse Models of Human Disease
OMIM IDRef(s)
Bothnia Retinal Dystrophy 607475 J:68444