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Phenotypes Associated with This Genotype
Genotype
MGI:3038416
Allelic
Composition
Rpgrtm1Tili/Rpgrtm1Tili
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpgrtm1Tili mutation (0 available); any Rpgr mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Light micrographs of retinal sections of wild-type and Rpgrtm1Tili/Rpgrtm1Tili mice.

vision/eye
• rhodopsins are not appreciably mislocalized but are reduced in the outer segments
• outer segment length is reduced at 6 months of age
• blue and green opsins are partially mislocalized to the inner segment, perinuclear, and synaptic regions
• substantial loss of photoreceptor cells by 6 months
• loss of nearly all cones by 2 years of age
• loss of 2/3 of rods by 2 years of age
• thickness of the outer nuclear layer is reduced at 6 months of age
• retinal degeneration apparently under way by 2 months of age
• reduction in photoreceptor nuclear layer thickness
• newly formed disk membranes are disorganized
• connecting cilia are normal
• retinal function normal at 30 days
• abnormal function appears in conjunction with morphological degeneration

nervous system
• rhodopsins are not appreciably mislocalized but are reduced in the outer segments
• outer segment length is reduced at 6 months of age
• blue and green opsins are partially mislocalized to the inner segment, perinuclear, and synaptic regions
• substantial loss of photoreceptor cells by 6 months
• loss of nearly all cones by 2 years of age
• loss of 2/3 of rods by 2 years of age


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory