Analysis Tools
cardiovascular system
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• irregular and reduced vascular network associated with the nasal bones, the mucosa underlying the nasal bones, and the vomeronasal organ
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craniofacial
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• lack of growth within the frontonasal sutures, putatively due to premature osteoblast differentiation
• diminished interdigitation of the frononasal sutures, whereas that of the premaxillary sutures is similar to wild-type
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• increased incidence of ectopic interfrontal which was observed in only 44% of all other mice, but in 100% of these conditional homozygotes
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• ~13% shorter than those of wild-type
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malocclusion
(
J:88829
)
|
• anterior shift of upper incisors as a result of altered arrangement of facial bones
|
|
• defects become evident between P10 and P21, increase with age, and are more severe at the distal end
• unlike wild-type, the nasal bones are ""concave"" from a lateral view and tend to be squared off
• increased mineralized portion relative to wild-type, putatively due to premature osteoblast differentiation and consequent inappropriate secretion of mineralized matrix that perturbs postnatal suture growth
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• abnormal and shortened by ~18% relative to those of wild-type
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• septal regions containing immature, rather than mature proliferating, chondrocytes
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short snout
(
J:88829
)
|
• due to impaired growth at the frontonasal suture
|
limbs/digits/tail
| N |
• no defects were observed in either the forelimbs or hindlimbs
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respiratory system
|
• defects become evident between P10 and P21, increase with age, and are more severe at the distal end
• unlike wild-type, the nasal bones are ""concave"" from a lateral view and tend to be squared off
• increased mineralized portion relative to wild-type, putatively due to premature osteoblast differentiation and consequent inappropriate secretion of mineralized matrix that perturbs postnatal suture growth
|
|
• abnormal and shortened by ~18% relative to those of wild-type
|
|
• septal regions containing immature, rather than mature proliferating, chondrocytes
|
skeleton
|
• lack of growth within the frontonasal sutures, putatively due to premature osteoblast differentiation
• diminished interdigitation of the frononasal sutures, whereas that of the premaxillary sutures is similar to wild-type
|
|
• increased incidence of ectopic interfrontal which was observed in only 44% of all other mice, but in 100% of these conditional homozygotes
|
|
• ~13% shorter than those of wild-type
|
malocclusion
(
J:88829
)
|
• anterior shift of upper incisors as a result of altered arrangement of facial bones
|
|
• defects become evident between P10 and P21, increase with age, and are more severe at the distal end
• unlike wild-type, the nasal bones are ""concave"" from a lateral view and tend to be squared off
• increased mineralized portion relative to wild-type, putatively due to premature osteoblast differentiation and consequent inappropriate secretion of mineralized matrix that perturbs postnatal suture growth
|
|
• abnormal and shortened by ~18% relative to those of wild-type
|
|
• septal regions containing immature, rather than mature proliferating, chondrocytes
|
vision/eye
growth/size/body
malocclusion
(
J:88829
)
|
• anterior shift of upper incisors as a result of altered arrangement of facial bones
|
|
• defects become evident between P10 and P21, increase with age, and are more severe at the distal end
• unlike wild-type, the nasal bones are ""concave"" from a lateral view and tend to be squared off
• increased mineralized portion relative to wild-type, putatively due to premature osteoblast differentiation and consequent inappropriate secretion of mineralized matrix that perturbs postnatal suture growth
|
|
• abnormal and shortened by ~18% relative to those of wild-type
|
|
• septal regions containing immature, rather than mature proliferating, chondrocytes
|
short snout
(
J:88829
)
|
• due to impaired growth at the frontonasal suture
|
