Phenotypes Associated with This Genotype

Genotype
MGI:3037835

• Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf; Trp53^tm1Brd/Trp53^tm1Brd
• Genetic Background: involves: C3H * C57BL/6J * NIH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:87536 )

• the most common type of tumor is T-cell lymphoma

mortality/aging

decreased tumor-free survival time ( J:87536 )

• the median latency to morbidity from tumor burden is significantly decreased in the double mutant compared to mice homozygous for Trp53^tm1Brd alone

• this effect is synergistic

neoplasm

increased tumor incidence ( J:87536 )

• the most common types of tumors are similar to mice homozygous for Trp53^tm1Brd alone, however additional tumor types are found in the double homozygous mice

increased T cell derived lymphoma incidence ( J:87536 )

• the most common type of tumor is T-cell lymphoma

increased sarcoma incidence ( J:87536 )

• the second most common types of tumor are sarcomas including; rhabdomyosarcoma, osteosarcoma, hemangiosarcoma, and poorly differentiated

hematopoietic system

increased T cell derived lymphoma incidence ( J:87536 )

• the most common type of tumor is T-cell lymphoma

immune system

increased T cell derived lymphoma incidence ( J:87536 )

• the most common type of tumor is T-cell lymphoma