Phenotypes Associated with This Genotype

Genotype
MGI:3037531

• Allelic Composition: Ppara^tm1Gonz/Ppara^tm1Gonz
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal epidermal layer morphology ( J:64345 )

abnormal keratinocyte differentiation ( J:64345 )

• foci of keratinocytes with nuclei are found in the stratum corneum

• mutants do not respond to peroxisome proliferators with thinning of the epidermis

decreased keratohyalin granule number ( J:64345 )

• fewer keratohylin granules within the granular cells

thin epidermis stratum granulosum ( J:64345 )

• the granular layer is thinner

cellular

abnormal keratinocyte differentiation ( J:64345 )

• foci of keratinocytes with nuclei are found in the stratum corneum

• mutants do not respond to peroxisome proliferators with thinning of the epidermis