Phenotypes Associated with This Genotype

Genotype
MGI:3037502

• Allelic Composition: Ppara^tm1Gonz/Ppara^tm1Gonz
• Genetic Background: B6.129S4-Ppara^tm1Gonz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased gonadal fat pad weight ( J:72185 )

• gonadal adipose stores are significantly larger in both female and male mutants

homeostasis/metabolism

abnormal circulating glucose level ( J:72932 )

• mutants do not respond to high fat diet with an increase in plasma glucose

abnormal circulating insulin level ( J:72932 )

• mutants do not respond to high fat diet with an increase in insulin levels

increased circulating triglyceride level ( J:72185 )

• serum concentrations of triglycerides are significantly higher in 9 month-old mutants on a C57BL/6N background

liver/biliary system

hepatic steatosis ( J:72185 )

• in 6 month old mutants hepatic accumulation of lipids is increased