Phenotypes Associated with This Genotype

Genotype
MGI:3037495

• Allelic Composition: Ppara^tm1Gonz/Ppara^tm1Gonz
• Genetic Background: 129S4/SvJae-Ppara^tm1Gonz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Accumulation of intracellular lipid in the liver of fasted Ppara^tm1Gonz/Ppara^tm1Gonz mice

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:56056 )

• 2 males out of 32 (male and female) mutants did not survive a 48 hour fast

adipose tissue

increased gonadal fat pad weight ( J:72185 )

• gonadal adipose stores are significantly larger in both female and male mutants

growth/size/body

increased body weight ( J:72185 )

• body weight is significantly elevated in male mutants on a 129S4/SvJae background compared to wild-type

enlarged liver ( J:56056 )

• after a 48 hour fast livers in mutant mice are slightly enlarged and appear pale

homeostasis/metabolism

abnormal circulating ketone body level ( J:56056 )

• fasting did not increase plasma ketone levels despite development of hypoglycemia

abnormal circulating HDL cholesterol level ( J:72185 )

• serum concentrations of HDL cholesterol are significantly higher in 9 month-old mutants on a 129S4/SvJae background compared to wild-type

increased circulating cholesterol level ( J:72185 )

• serum concentrations of cholesterol are significantly higher in 9 month-old mutants on a 129S4/SvJae background compared to wild-type

increased circulating free fatty acids level ( J:56056 )

• after fasting mutants exhibit abnormally high levels of circulating free fatty acids

abnormal glucose homeostasis ( J:56056 )

• in fasted mutants the initial drop in mean blood glucose levels is significantly greater than in fasted wild-types

abnormal circulating glucose level ( J:72932 )

• mutants do not respond to high fat diet with an increase in plasma glucose

abnormal circulating insulin level ( J:72932 )

• mutants do not respond to high fat diet with an increase in insulin levels

insulin resistance ( J:72932 )

• mutants on a 129S4/SvJae background fed a high fat diet do not develop insulin resistance

liver/biliary system

enlarged liver ( J:56056 )

• after a 48 hour fast livers in mutant mice are slightly enlarged and appear pale

hepatic steatosis ( J:56056 , J:72185 )

• lipid accumulation in the hepatocytes of fasted mutants is massive and homogeneous rather than exhibiting a regional pattern as in wild-types (J:56056)

• the majority of the lipid accumulation is in the triglyceride fraction (J:56056)

• in 6 month old mutants hepatic accumulation of lipids is increased (J:72185)

cardiovascular system

abnormal myocardium layer morphology ( J:56056 )

• patchy regions of neutral lipid accumulation are found in the myocardium after fasting

muscle

abnormal myocardium layer morphology ( J:56056 )

• patchy regions of neutral lipid accumulation are found in the myocardium after fasting