Mouse Genome Informatics
hm
    Sh2d1atm1Pls/Sh2d1atm1Pls
either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * C57BL/6)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
hematopoietic system
• although lymphocyte numbers were generally normal, occasional animals had increased T cell and NK cell numbers together with decreased B cell numbers in the spleen (J:70032)
• tendency for T-cell proliferation to be increased even in the absence of infection (J:70032)
• biased toward the production of the Th1 cytokines Il-2 and IFN-gamma (J:70032)
• biased toward decreased production of the Th2 cytokine Il-4 (J:70032)
• although levels of IgM, IgG, and IgA were normal, IgE levels were reduced (J:70032)

immune system
• although lymphocyte numbers were generally normal, occasional animals had increased T cell and NK cell numbers together with decreased B cell numbers in the spleen (J:70032)
• tendency for T-cell proliferation to be increased even in the absence of infection (J:70032)
• biased toward the production of the Th1 cytokines Il-2 and IFN-gamma (J:70032)
• biased toward decreased production of the Th2 cytokine Il-4 (J:70032)
• although levels of IgM, IgG, and IgA were normal, IgE levels were reduced (J:70032)
• elevated T-cell response to Toxoplasma gondii infection (J:70032)
• lower titers of Ig isotypes directed against Toxoplasma antigens (J:70032)
• increased T-cell response to infection with lymphocyte choriomeningitis virus (LCMV) (J:70032)
• Elevated activity of CD8+ cytotoxic T lymphocytes in spleen (J:70032)
• CD4+ cells also increased 2-3X (J:70032)
• decrease in antibody secreting cells in spleen and bone marrow (J:70032)
• more virulent strains led to increased morbidity (J:70032)

Mouse Models of Human Disease
OMIM IDRef(s)
Lymphoproliferative Syndrome, X-Linked, 1; XLP1 308240 J:70032