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Phenotypes Associated with This Genotype
Genotype
MGI:3036852
Allelic
Composition
Sim1tm1Fan/Sim1+
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sim1tm1Fan mutation (0 available); any Sim1 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• cells are larger (J:70586)
• cells are larger (J:70586)
• mass of brown fat was increased (J:70586)
• mass of brown fat was increased (J:70586)
• white adipose tissue cells are histologically normal (J:70586)
• white adipose tissue cells are histologically normal (J:70586)
• increased mass of white fat due to increased number of cells (J:70586)
• increased mass of white fat due to increased number of cells (J:70586)

behavior/neurological
• food intake increased around 4-5 weeks of age (J:70586)
• hyperphagia persists over time (J:70586)
• food intake increased around 4-5 weeks of age (J:70586)
• hyperphagia persists over time (J:70586)

growth/size/body
• heterozygotes have a greater naso-anal length after 4 weeks than do controls (J:70586)
• heterozygotes have a greater naso-anal length after 4 weeks than do controls (J:70586)
• while growth is normal until 4 weeks of age, weight gain after that time is elevated in both males and females (J:70586)
• while growth is normal until 4 weeks of age, weight gain after that time is elevated in both males and females (J:70586)

homeostasis/metabolism
• blood glucose levels were normal at 8 and 24 weeks of age (J:70586)
• blood glucose levels were normal at 8 and 24 weeks of age (J:70586)
• although normal at 8 weeks, insulin levels were significantly elevated by 24 weeks of age (J:70586)
• while growth is normal until 4 weeks of age, weight gain after that time is elevated in both males and females (J:70586)
• although normal at 8 weeks, insulin levels were significantly elevated by 24 weeks of age (J:70586)
• while growth is normal until 4 weeks of age, weight gain after that time is elevated in both males and females (J:70586)

nervous system
• paraventricular nucleus and supraoptic nuclei are hypocellular (J:50772)
• paraventricular nucleus and supraoptic nuclei are hypocellular (J:50772)

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:70586


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory