Mouse Genome Informatics
ht
    Sim1tm1Fan/Sim1+
involves: 129/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
adipose tissue
• mass of brown fat was increased
• white adipose tissue cells are histologically normal
• increased mass of white fat due to increased number of cells

behavior/neurological
• food intake increased around 4-5 weeks of age
• hyperphagia persists over time

growth/size
• heterozygotes have a greater naso-anal length after 4 weeks than do controls
• while growth is normal until 4 weeks of age, weight gain after that time is elevated in both males and females

homeostasis/metabolism
• blood glucose levels were normal at 8 and 24 weeks of age
• although normal at 8 weeks, insulin levels were significantly elevated by 24 weeks of age
• while growth is normal until 4 weeks of age, weight gain after that time is elevated in both males and females

nervous system
• paraventricular nucleus and supraoptic nuclei are hypocellular

Mouse Models of Human Disease
OMIM IDRef(s)
Obesity 601665 J:70586