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Phenotypes Associated with This Genotype
Genotype
MGI:3035937
Allelic
Composition
Grip1tm1Rha/Grip1tm1Rha
Genetic
Background
B6.129-Grip1tm1Rha
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grip1tm1Rha mutation (1 available); any Grip1 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• Background Sensitivity: mice that had been backcrossed to C57BL/6 for 6 generations develop to term

limbs/digits/tail
• observed in hindlimbs of mice that developed to E16.5
• observed in hindlimbs of mice that developed to E16.5

renal/urinary system
• at E13.5, unstructured mesenchymal rudiments devoid of metanephric tubules and containing large numbers of apoptotic cells

integument
• formation of large subepidermal blisters underneath the epidermal basement membrane of the head, limb, and back skin
• initially transparent when first observed at E11, but blisters became hemorrhagic
• blisters subsided in mice that survived to late gestation

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Fraser syndrome DOID:0090001 OMIM:PS219000
J:88266


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2022
MGI 6.21
The Jackson Laboratory