Phenotypes Associated with This Genotype

Genotype
MGI:3035906

• Allelic Composition: Cd40^tm1Kik/Cd40^tm1Kik
• Genetic Background: B6.129P2-Cd40^tm1Kik/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:75152 )

N • normal thrombogenesis in ferric-chloride-induced injury of mesenteric arterioles

decreased platelet aggregation ( J:108988 )

• reduced number of rolling platelets and 50% attenuation in platelet adhesion following 1 hour of middle cerebral artery occlusion and 4 hours of reperfusion

immune system

abnormal dendritic cell physiology ( J:86998 )

• impaired production of IL-12 after Mycobacterium tuberculosis infection and after incubation with Hsp7

• impaired priming of IFN-gamma producing T cells

increased susceptibility to bacterial infection ( J:86998 )

• increased susceptibility to aerosol Mycobacterium tuberculosis infection

• increased bacterial loads in lung and spleen

• 40% of infected mice moribund 3 - 4 weeks postinfection

homeostasis/metabolism

decreased platelet aggregation ( J:108988 )

• reduced number of rolling platelets and 50% attenuation in platelet adhesion following 1 hour of middle cerebral artery occlusion and 4 hours of reperfusion

decreased cerebral infarct size ( J:108988 )

• significantly reduced infarct volumes

nervous system

decreased cerebral infarct size ( J:108988 )

• significantly reduced infarct volumes

skeleton

decreased bone mineral density ( J:145330 )

• significantly reduced

decreased compact bone mass ( J:145330 )

• significantly reduced

decreased trabecular bone mass ( J:145330 )

• significantly reduced