Analysis Tools
mortality/aging
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• death occurred around the 1st week of age
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growth/size/body
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• although of normal size at birth, homozygotes became noticeably smaller than normal by 3-4 days of age
• by 7 days of age homozygotes were severely runted (1/3 normal weight)
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hematopoietic system
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• elevated numbers of granulocyte precursors in bone marrow and spleen as animals age
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• atrophy in mice over 6 days of age
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• after 6 days
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• 3 fold increase in peripheral WBC count - about 95% neutrophils
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• small size by day 2 with a worsening size reduction until death
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immune system
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• elevated numbers of granulocyte precursors in bone marrow and spleen as animals age
|
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• atrophy in mice over 6 days of age
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• after 6 days
|
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• 3 fold increase in peripheral WBC count - about 95% neutrophils
|
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• small size by day 2 with a worsening size reduction until death
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integument
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• poorly defined basal layer
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flaky skin
(
J:30058
)
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• significant sloughing
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scaly skin
(
J:30058
)
cellular
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• elevated numbers of granulocyte precursors in bone marrow and spleen as animals age
|
endocrine/exocrine glands
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• atrophy in mice over 6 days of age
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