Phenotypes for Dph1 Trp53 MGI:3033460 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Dph1^tm2Bhr/Dph1^tm2Bhr Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dph1^tm2Bhr mutation (0 available); any Dph1 mutation (26 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (237 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:88090 )

• homozygotes die soon after birth

embryonic lethality during organogenesis, incomplete penetrance ( J:88090 )

• 30-50% of embryos die between E11.5 and E13.5

cellular

cellular phenotype ( J:88090 )

N	• proliferation defect in cultured MEFs rescued by this genotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 01/13/2026 MGI 6.24