Phenotypes for Dph1 Trp53 MGI:3033460 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Dph1^tm2Bhr/Dph1^tm2Bhr Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dph1^tm2Bhr mutation (0 available); any Dph1 mutation (25 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (249 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:88090 )

• homozygotes die soon after birth

embryonic lethality during organogenesis, incomplete penetrance ( J:88090 )

• 30-50% of embryos die between E11.5 and E13.5

cellular

cellular phenotype ( J:88090 )

N	• proliferation defect in cultured MEFs rescued by this genotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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