Phenotypes Associated with This Genotype

Genotype
MGI:3032926

• Allelic Composition: Fasl^tm1.1Lest/Fasl^tm1.1Lest
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:87990 )

• reduced survival due to massive lymphoproliferation and autoimmune disease

• greater than 50% died by 4 months

• 85% had died by 7 months

endocrine/exocrine glands

abnormal salivary gland morphology ( J:87990 )

• lymphocytic infiltration

hematopoietic system

enlarged spleen ( J:87990 )

• more accelerated and pronounced than in homozygous Tnfsf6^gld mice on a C57BL/6 genetic background

abnormal double-negative T cell morphology ( J:87990 )

• abnormal CD3⁺B220⁺CD4^-CD8^- T cells represented 70% to 87% of the cells that accumulated in the spleen and lymph nodes at 12 to 13 weeks of age

increased IgG level ( J:87990 )

• hypergammaglobulinemia

• significantly higher than those observed in wild-type controls and in homozygous Tnfsf6^gld mice

homeostasis/metabolism

increased urine protein level ( J:87990 )

• observed in most mice with a mixed genetic background involving 129/Sv and C57BL/6 as well as in incipient congenic mice (backcrossed to C57BL/6 for 5 generations)

immune system

enlarged spleen ( J:87990 )

• more accelerated and pronounced than in homozygous Tnfsf6^gld mice on a C57BL/6 genetic background

abnormal double-negative T cell morphology ( J:87990 )

• abnormal CD3⁺B220⁺CD4^-CD8^- T cells represented 70% to 87% of the cells that accumulated in the spleen and lymph nodes at 12 to 13 weeks of age

increased IgG level ( J:87990 )

• hypergammaglobulinemia

• significantly higher than those observed in wild-type controls and in homozygous Tnfsf6^gld mice

abnormal lymph node morphology ( J:87990 )

• lymphadenopathy associated with lymphocytic infiltration into multiple organs

• more accelerated and pronounced than in homozygous Tnfsf6^gld mice on a C57BL/6 genetic background

enlarged lymph nodes ( J:87990 )

lymphoid hyperplasia ( J:87990 )

• lymphoproliferation of both normal B and T cells as well as abnormal double negative T cells in spleen and lymph nodes

autoimmune response ( J:87990 )

glomerulonephritis ( J:87990 )

• observed in most mice with a mixed genetic background involving 129/Sv and C57BL/6 as well as in incipient congenic mice (backcrossed to C57BL/6 for 5 generations)

liver/biliary system

enlarged liver ( J:87990 )

• associated with moderate to severe lymphocytic infiltration

renal/urinary system

increased urine protein level ( J:87990 )

• observed in most mice with a mixed genetic background involving 129/Sv and C57BL/6 as well as in incipient congenic mice (backcrossed to C57BL/6 for 5 generations)

glomerulonephritis ( J:87990 )

• observed in most mice with a mixed genetic background involving 129/Sv and C57BL/6 as well as in incipient congenic mice (backcrossed to C57BL/6 for 5 generations)

digestive/alimentary system

abnormal salivary gland morphology ( J:87990 )

• lymphocytic infiltration

growth/size/body

enlarged liver ( J:87990 )

• associated with moderate to severe lymphocytic infiltration

enlarged spleen ( J:87990 )

• more accelerated and pronounced than in homozygous Tnfsf6^gld mice on a C57BL/6 genetic background