Phenotypes Associated with This Genotype

Genotype
MGI:3028879

• Allelic Composition: Pou2f1^tm1Shrp/Pou2f1^tm1Shrp
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:87664 )

• lethality begins at E12 and continues close to birth; no viable embryos are found at birth

embryonic lethality during organogenesis, incomplete penetrance ( J:87664 )

• Background Sensitivity: on mixed background involving 129S4/SvJae and C57BL/6, death occurs during a window spanning from approximately E12 through birth

• Background Sensitivity: embryonic lethality occurs earlier with successive backcrosses to either C57BL/6 or 129/Sv

hematopoietic system

abnormal erythropoiesis ( J:87664 )

• decrease in erythropoiesis at E12.5

anemia ( J:87664 )

embryo

decreased embryo size ( J:87664 )

• 3.6% of embryos at E13.5 are runted

growth/size/body

decreased embryo size ( J:87664 )

• 3.6% of embryos at E13.5 are runted

liver/biliary system

small liver ( J:87664 )

• subset of mutants have small fetal livers

vision/eye

vision/eye phenotype ( J:119175 )

N • lens placode induction and subsequent lens morphogenesis appears normal, with some embryos having morphologically normal,small lens pits

small lens ( J:119175 )

• some embryos at E10.5 have small lenses

integument

pallor ( J:87664 )

• subset of embryos appear pale