Phenotypes Associated with This Genotype

Genotype
MGI:3028610

• Allelic Composition: Ncor1^tm1Rsd/Ncor1^tm1Rsd
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:65417 )

• most embryos die by E15.5; no viable embryos found aby E18.5

embryo

decreased embryo size ( J:65417 )

• embryos are 50% smaller than littermates

growth/size/body

decreased embryo size ( J:65417 )

• embryos are 50% smaller than littermates

hematopoietic system

small thymus ( J:65417 )

abnormal erythropoiesis ( J:65417 )

• defect in definitive but not primitive erythropoiesis

arrested T cell differentiation ( J:65417 )

• thymocytes are blocked in the CD4^-/ CD8^- stage; CD25⁺/ CD44^- thymocytes were detected; cells can be induced to develop into CD4⁺/ CD8⁺ cells by treatment with anti-CD3epsilon antibodies

anemia ( J:65417 )

• increasing severity with age

decreased erythrocyte cell number ( J:65417 )

• fewer nonnucleated erythrocytes

abnormal hematocrit ( J:65417 )

decreased hematocrit ( J:65417 )

• apparent at E14.5

increased nucleated erythrocyte cell number ( J:65417 )

• increased number of nucleated erythroblasts

homeostasis/metabolism

edema ( J:65417 )

• seen in approximately 50% of embryos; progressive with age

immune system

small thymus ( J:65417 )

arrested T cell differentiation ( J:65417 )

• thymocytes are blocked in the CD4^-/ CD8^- stage; CD25⁺/ CD44^- thymocytes were detected; cells can be induced to develop into CD4⁺/ CD8⁺ cells by treatment with anti-CD3epsilon antibodies

liver/biliary system

abnormal hepatocyte morphology ( J:65417 )

• fetal liver cells have a reduced ability to form BFU-E colonies in culture

small liver ( J:65417 )

• the liver is half the size of wild-type

nervous system

dilated third ventricle ( J:65417 )

small thalamus ( J:65417 )

• reduced overall size of the thalamus; small thalamic nuclei were noted including the lateral geniculate nuclei

integument

pallor ( J:65417 )

• noted in embryos from E13.5; probably due to anemia

endocrine/exocrine glands

small thymus ( J:65417 )