Phenotypes Associated with This Genotype

Genotype
MGI:3028537

• Allelic Composition: Ss18l1^tm1Ghsh/Ss18l1^tm1Ghsh
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:87443 )

• increased mortality starting about day 14

• 80% dead by day 28

behavior/neurological

impaired coordination ( J:87443 )

growth/size/body

decreased body size ( J:87443 )

• although indistinguishable from wild-type at birth, homozygotes grew more slowly

reproductive system

infertility ( J:87443 )

• of the less than 20% who survived to adulthood, all were infertile

nervous system

abnormal forebrain morphology ( J:87443 )

• dendritic growth and branching compromised by day 7

abnormal hippocampus CA3 region morphology ( J:87443 )

• dendritic length reduced 50-80% in hippocampal CA3 neurons

abnormal cerebral cortex morphology ( J:87443 )

• cortex is reduced in size

• dendritic length reduced 50-80% in cortical layer 5

• dendritic branching in cortical neurons is reduced

abnormal hindbrain morphology ( J:87443 )

small cerebellum ( J:87443 )