Phenotypes Associated with This Genotype

Genotype
MGI:3027518

• Allelic Composition: Mst1r^tm1Ber/Mst1r^tm1Ber
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:76451 )

N • normal hematopoiesis

abnormal macrophage physiology ( J:76451 )

• peritoneal macrophages produced elevated NO concentrations upon stimulation with IFN-g, without the need for secondary, co-stimulatory, signal

• stimulation with LPS did not result in increased production of cytokines (TNF-a, IL-1b, IL-6, or IL-12), however

abnormal type IV hypersensitivity reaction ( J:76451 )

• increased inflammation in delayed type hypersensitivity reaction, using oxazolone as the sensitizing agent

increased inflammatory response ( J:76451 )

• in delayed type hypersensitivity reaction, using oxazolone as the sensitizing agent

increased susceptibility to bacterial infection ( J:76451 )

• more susceptible to LPS-induced death than littermate controls

• serum levels of pro-inflammatory cytokines (TNF-a, IL-1b, IL-6, or IL-12) were similar to control animals, however

hematopoietic system

abnormal macrophage physiology ( J:76451 )

• peritoneal macrophages produced elevated NO concentrations upon stimulation with IFN-g, without the need for secondary, co-stimulatory, signal

• stimulation with LPS did not result in increased production of cytokines (TNF-a, IL-1b, IL-6, or IL-12), however