Mst1r^tm1Ber
Targeted Allele Detail

Summary

• Symbol: Mst1r^tm1Ber
• Name: macrophage stimulating 1 receptor (c-met-related tyrosine kinase); targeted mutation 1, Alan Bernstein
• MGI ID: MGI:2180765
• Synonyms: Ron^-, stk -
• Gene: Mst1r Location: Chr9:107784072-107797582 bp, + strand Genetic Position: Chr9, 59.07 cM, cytoband F1
• Alliance: Mst1r^tm1Ber page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76451
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An 850 bp fragment surrounding exon 1 was replaced with a lacZ gene and neomycin selection cassette. Beta-galactosidase is expressed from this allele under the control of the endogenous promoter. FACS analysis on peritoneal macrophages derived from homozygous mice confirmed that no functional encoded protein was present on the cell surface. (J:76451)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mst1r Mutation: 59 strains or lines available

References

• Original: J:76451 Correll PH, et al., Deregulated inflammatory response in mice lacking the STK/RON receptor tyrosine kinase. Genes Funct. 1997 Feb;1(1):69-83
• All: 9 reference(s)