Phenotypes Associated with This Genotype

Genotype
MGI:2687206

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Tg(Pdx1-cre)89.1Dam/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:116130 , J:164210 )

• average cancer free survival is greater than 52 weeks and 2 of 9 mice develop pancreatic ductal adenocarcinoma (J:116130)

• 2 of 11 mutants show evidence of pancreatic ductal adenocarcinoma at 6 months of age, but not at earlier times (J:164210)

increased pancreatic intraepithelial neoplasia incidence ( J:87196 , J:164210 )

• pancreatic ductal lesions are seen at 9, 12, 18, and 26 weeks of are, similar to human pancreatic intraepithelial neoplasias (PanINs) (J:87196)

• PanINs increase in number and size with age, however no invasive tumors are seen up to 30 weeks of age (J:87196)

• no evidence of neoplasia in the acinar cell compartment, however focal reactive metaplastic changes are seen (J:87196)

• low-grade mPanIN lesions are seen in 3 month old mutants and by 6 months of age, most mice exhibit mPanIN lesions (J:164210)

endocrine/exocrine glands

enlarged pancreatic islets ( J:87196 )

• pancreatic islets are moderately enlarged but do not show evidence of neoplasia

increased pancreatic ductal adenocarcinoma incidence ( J:116130 , J:164210 )

• average cancer free survival is greater than 52 weeks and 2 of 9 mice develop pancreatic ductal adenocarcinoma (J:116130)

• 2 of 11 mutants show evidence of pancreatic ductal adenocarcinoma at 6 months of age, but not at earlier times (J:164210)

increased pancreatic intraepithelial neoplasia incidence ( J:87196 , J:164210 )

• pancreatic ductal lesions are seen at 9, 12, 18, and 26 weeks of are, similar to human pancreatic intraepithelial neoplasias (PanINs) (J:87196)

• PanINs increase in number and size with age, however no invasive tumors are seen up to 30 weeks of age (J:87196)

• no evidence of neoplasia in the acinar cell compartment, however focal reactive metaplastic changes are seen (J:87196)

• low-grade mPanIN lesions are seen in 3 month old mutants and by 6 months of age, most mice exhibit mPanIN lesions (J:164210)

pancreatic acinar-to-ductal metaplasia ( J:164210 )

• acinar-to-ductal metaplasia is seen at 1 week of age

growth/size/body

distended abdomen ( J:164210 )

• most mutants exhibit abdominal distention due to ascites fluid and pancreatic enlargement

homeostasis/metabolism

ascites ( J:164210 )