Phenotypes Associated with This Genotype

Genotype
MGI:2687088

• Allelic Composition: Pomc^tm2Ute/Pomc^tm2Ute
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:57503 )

• homozygotes are born to heterozygous parents at 1/4 the frequency expected

growth/size/body

obese ( J:57503 )

• mutants begin gaining weight in the second month after birth and by the third month of age, they are about twice the weight of wild-type

• mice treated with a stable alpha-melanocyte-stimulating hormone agonist lost more than 40% of their excess weight in 2 weeks

increased body length ( J:57503 )

• the weight gain in accompanied by a slight, but significant, increase in body length

increased susceptibility to diet-induced obesity ( J:57503 )

• mutants show an increased rate of weight gain on a high fat diet

pigmentation

yellow coat color ( J:57503 )

• coat covering the sides and belly is more yellow than in wild-type and the tips of the hairs at the back have a more yellowish tinge

diluted coat color ( J:57503 )

endocrine/exocrine glands

absent adrenal gland ( J:57503 )

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:57503 )

• mutants show an increased rate of weight gain on a high fat diet

decreased circulating adrenaline level ( J:57503 )

decreased circulating corticosterone level ( J:57503 )

• serum corticosterone is below detectable levels

increased circulating leptin level ( J:57503 )

• weight gain is accompanied by a large increase in serum leptin levels

decreased circulating aldosterone level ( J:57503 )

• serum aldosterone is below detectable levels

decreased circulating adrenocorticotropin level ( J:57503 )

increased dopamine level ( J:57503 )

• dopamine levels are slightly higher

behavior/neurological

increased food intake ( J:57503 )

• mutants have a greater food intake than wild-type on both a regular or high-fat diet

integument

yellow coat color ( J:57503 )

• coat covering the sides and belly is more yellow than in wild-type and the tips of the hairs at the back have a more yellowish tinge

diluted coat color ( J:57503 )