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Phenotypes Associated with This Genotype
Genotype
MGI:2686902
Allelic
Composition
Mpltm1Fjs/Mpltm1Fjs
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpltm1Fjs mutation (0 available); any Mpl mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• levels of megakaryocyte progenitors reduced by about 50%
• fewer megakaryocytes generated in response to thrombopoietin and the ploidy of cells produced was lower
• less of an increase in platelets 5 days after thrombopoietin treatment

Mouse Models of Human Disease
OMIM ID Ref(s)
Amegakaryocytic Thrombocytopenia, Congenital; CAMT 604498 J:87416


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory