Phenotypes Associated with This Genotype

Genotype
MGI:2684777

• Allelic Composition: Malt1^tm1Vmd/Malt1^tm1Vmd
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell proliferation ( J:86770 )

• defect in T cell proliferation at a stage before cell growth

abnormal B cell differentiation ( J:86770 )

• defect of immature B cells or of T1 subset or of the marginal zone and B1 cells

abnormal T cell differentiation ( J:86770 )

abnormal double-negative T cell morphology ( J:86770 )

• numbers of double negative cells in DN3 stage is reduced while increased numbers of cells are in DN4 stage

• an indication of premature maturation

absent B-1a cells ( J:86770 )

• lack of peritoneal CD⁺IGM⁺CD5⁺ B cells

abnormal spleen marginal zone morphology ( J:86770 )

• width of marginal zone B cell area is barely detectable

decreased immunoglobulin level ( J:86770 )

• basal immunoglobulin serum levels are reduced

immune system

abnormal T cell proliferation ( J:86770 )

• defect in T cell proliferation at a stage before cell growth

decreased immunoglobulin level ( J:86770 )

• basal immunoglobulin serum levels are reduced

abnormal immune system morphology ( J:86770 )

abnormal B cell differentiation ( J:86770 )

• defect of immature B cells or of T1 subset or of the marginal zone and B1 cells

abnormal T cell differentiation ( J:86770 )

abnormal double-negative T cell morphology ( J:86770 )

• numbers of double negative cells in DN3 stage is reduced while increased numbers of cells are in DN4 stage

• an indication of premature maturation

absent B-1a cells ( J:86770 )

• lack of peritoneal CD⁺IGM⁺CD5⁺ B cells

abnormal spleen marginal zone morphology ( J:86770 )

• width of marginal zone B cell area is barely detectable

decreased interleukin-2 secretion ( J:86770 )

• less Il-2 is produced

cellular

abnormal T cell proliferation ( J:86770 )

• defect in T cell proliferation at a stage before cell growth