Phenotypes Associated with This Genotype

Genotype
MGI:2684658

• Allelic Composition: Psen1^tm1Vln/Psen1^tm1Vln; Tg(Thy1-APPLon)2Vln/0; Tg(Thy1-cre)1Vln/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal object recognition memory ( J:87229 )

• retention of object recognition is normal at 1 hr after training but testing of animals 3 hours after familiarization with an object reveals significant impairment relative to controls

nervous system

nervous system phenotype ( J:87229 )

N • no thioflavin-S-reactive amyloid plaques or diffuse amyloid deposits are detected in mice up to 18 months of age

abnormal long-term potentiation ( J:87229 )

• with tetanic stimulation of hippocampal slices, after an initial slight decrease, the slope of the fEPSP approached control levels; LTP in transgenic brain slices is comparable to controls