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Phenotypes Associated with This Genotype
Genotype
MGI:2684657
Allelic
Composition
Psen1tm1Vln/Psen1tm1Vln
Tg(Thy1-cre)1Vln/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Vln mutation (2 available); any Psen1 mutation (28 available)
Tg(Thy1-cre)1Vln mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice do not display any behavioral or cognitive deficits

nervous system
N
• brains of 6 month-old mice do not show any morphological abnormalities like cerebral hemorrhages, cavities or tumors; no defects are observed up to 2 years of age
• levels of amyloid beta-40 and -42 (Abeta40, Abeta42) are reduced relative to controls; C-terminal fragments of APP accumulate in brains
• initial phase of the slope of fEPSP is lower (168% vs 221% in controls) 15 minutes after tetanic stimulation; slope of fEPSP progressively increases to approach control levels 2 hours following stimulation

homeostasis/metabolism
• levels of amyloid beta-40 and -42 (Abeta40, Abeta42) are reduced relative to controls; C-terminal fragments of APP accumulate in brains

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease 3 607822 J:87229
Alzheimer Disease; AD 104300 J:87229


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory