Mouse Genome Informatics
cn
    Psen1tm1Vln/Psen1tm1Vln
Tg(Thy1-cre)1Vln/0

involves: FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
N
• mice do not display any behavioral or cognitive deficits (J:87229)

nervous system
N
• brains of 6 month-old mice do not show any morphological abnormalities like cerebral hemorrhages, cavities or tumors; no defects are observed up to 2 years of age (J:87229)
• levels of amyloid beta-40 and -42 (Abeta40, Abeta42) are reduced relative to controls; C-terminal fragments of APP accumulate in brains
• initial phase of the slope of fEPSP is lower (168% vs 221% in controls) 15 minutes after tetanic stimulation; slope of fEPSP progressively increases to approach control levels 2 hours following stimulation

homeostasis/metabolism
• levels of amyloid beta-40 and -42 (Abeta40, Abeta42) are reduced relative to controls; C-terminal fragments of APP accumulate in brains

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease 3 607822 J:87229
Alzheimer Disease; AD 104300 J:87229