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Phenotypes Associated with This Genotype
Genotype
MGI:2684442
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Rac1tm1Tyb/Rac1tm1Tyb
Rac2tm1Mddw/Rac2tm1Mddw
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Rac1tm1Tyb mutation (0 available); any Rac1 mutation (26 available)
Rac2tm1Mddw mutation (1 available); any Rac2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested B cell differentiation ( J:86765 )
• development blocked at the T1 stage
decreased transitional stage B cell number ( J:86765 )
• diminished splenic T1 and T2 cells
decreased B-1 B cell number ( J:86765 )
• peritoneal B cells (B1) also reduced
decreased follicular B cell number ( J:86765 )
• diminished recirculating follicular B cells
decreased marginal zone B cell number ( J:86765 )
• splenic marginal B cells were reduced

immune system
arrested B cell differentiation ( J:86765 )
• development blocked at the T1 stage
decreased transitional stage B cell number ( J:86765 )
• diminished splenic T1 and T2 cells
decreased B-1 B cell number ( J:86765 )
• peritoneal B cells (B1) also reduced
decreased follicular B cell number ( J:86765 )
• diminished recirculating follicular B cells
decreased marginal zone B cell number ( J:86765 )
• splenic marginal B cells were reduced

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory