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Phenotypes Associated with This Genotype
Genotype
MGI:2684174
Allelic
Composition		 Mcl1tm2Sjk/Mcl1tm3Sjk
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcl1tm2Sjk mutation (1 available); any Mcl1 mutation (36 available)
Mcl1tm3Sjk mutation (1 available); any Mcl1 mutation (36 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:86906 )
• peripheral B cells are not maintained
decreased T cell number ( J:86906 )
• peripheral T cells are not maintained

immune system
decreased B cell number ( J:86906 )
• peripheral B cells are not maintained
decreased T cell number ( J:86906 )
• peripheral T cells are not maintained

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory