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Phenotypes Associated with This Genotype
Genotype
MGI:2684157
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Mcl1tm2Sjk/Mcl1tm3Sjk
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Mcl1tm2Sjk mutation (1 available); any Mcl1 mutation (33 available)
Mcl1tm3Sjk mutation (1 available); any Mcl1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased B cell apoptosis ( J:86906 )
• increased apoptosis at pro-B cell stage
arrested B cell differentiation ( J:86906 )
• arrested at pro-B cell stage
decreased B cell number ( J:86906 )
• decrease in peripheral B cells
• 88% reduction of splenic B cells relative to controls
• near absence of lymph node B cells
• detected peripheral B cells did not undergo cre-mediated recombination

immune system
increased B cell apoptosis ( J:86906 )
• increased apoptosis at pro-B cell stage
arrested B cell differentiation ( J:86906 )
• arrested at pro-B cell stage
decreased B cell number ( J:86906 )
• decrease in peripheral B cells
• 88% reduction of splenic B cells relative to controls
• near absence of lymph node B cells
• detected peripheral B cells did not undergo cre-mediated recombination

cellular
increased B cell apoptosis ( J:86906 )
• increased apoptosis at pro-B cell stage

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory