Phenotypes Associated with This Genotype

Genotype
MGI:2684156

• Allelic Composition: Mcl1^tm2Sjk/Mcl1^tm3Sjk; Tg(Lck-cre)1Cwi/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased T cell apoptosis ( J:86906 )

• increased apoptosis at double negative T cell stage

arrested T cell differentiation ( J:86906 )

• block at the double-negative stage between DN2 and DN3

decreased T cell number ( J:86906 )

• decreased number of peripheral T cells

• detected peripheral T cells did not undergo cre-mediated recombination

decreased thymocyte number ( J:86906 )

• reduction of the total number of thymocytes

decreased double-negative T cell number ( J:86906 )

• reduction of double-negative cells in DN3 and DN4 subsets, but not in DN1 or DN2 subsets

decreased double-positive T cell number ( J:86906 )

immune system

increased T cell apoptosis ( J:86906 )

• increased apoptosis at double negative T cell stage

arrested T cell differentiation ( J:86906 )

• block at the double-negative stage between DN2 and DN3

decreased T cell number ( J:86906 )

• decreased number of peripheral T cells

• detected peripheral T cells did not undergo cre-mediated recombination

decreased thymocyte number ( J:86906 )

• reduction of the total number of thymocytes

decreased double-negative T cell number ( J:86906 )

• reduction of double-negative cells in DN3 and DN4 subsets, but not in DN1 or DN2 subsets

decreased double-positive T cell number ( J:86906 )

cellular

increased T cell apoptosis ( J:86906 )

• increased apoptosis at double negative T cell stage

endocrine/exocrine glands

decreased thymocyte number ( J:86906 )

• reduction of the total number of thymocytes