Mouse Genome Informatics
hm
    Icostm1Shr/Icostm1Shr
Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
hematopoietic system
• after immunization with alum or incomplete Freund's adjuvant, germinal centers were reduced in size and number
• organization of germinal centers remained normal
• IgM response remained normal
• production of IgE extremely low or absent
• IgG3 levels were slightly elevated
• after immunization with alum or incomplete Freund's adjuvant
• reduction of IgG1 levels to under 2% of normal
• reduction of IgG2a level to around 6% of normal
• proliferation reduced

immune system
• after immunization with alum or incomplete Freund's adjuvant, germinal centers were reduced in size and number
• organization of germinal centers remained normal
• IgM response remained normal
• production of IgE extremely low or absent
• IgG3 levels were slightly elevated
• after immunization with alum or incomplete Freund's adjuvant
• reduction of IgG1 levels to under 2% of normal
• reduction of IgG2a level to around 6% of normal
• proliferation reduced
• Il-4 levels not detectable
• Il-10 levels not detectable

homeostasis/metabolism
• Il-4 levels not detectable
• Il-10 levels not detectable

Mouse Models of Human Disease
OMIM IDRef(s)
Immunodeficiency, Common Variable, 1; CVID1 607594 J:87124