Phenotypes Associated with This Genotype

Genotype
MGI:2683606

• Allelic Composition: Icosl^tm1Cdon/Icosl^tm1Cdon
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell differentiation ( J:86697 )

small spleen ( J:86697 )

• much smaller spleens

• about 1/3 as many cells as in wild-type mice

abnormal immunoglobulin level ( J:86697 )

decreased IgE level ( J:86697 )

• production of IgE essentially absent

decreased IgG level ( J:86697 )

• moderate reductions of IgG1 and IgG2a levels

decreased IgG1 level ( J:86697 )

decreased IgG2a level ( J:86697 )

decreased IgM level ( J:86697 )

• significantly reduced levels

abnormal T-helper 2 physiology ( J:86697 )

• defect indicated by low Il-4 levels and low IgF1 and IgE levels

immune system

abnormal T cell differentiation ( J:86697 )

small spleen ( J:86697 )

• much smaller spleens

• about 1/3 as many cells as in wild-type mice

abnormal immunoglobulin level ( J:86697 )

decreased IgE level ( J:86697 )

• production of IgE essentially absent

decreased IgG level ( J:86697 )

• moderate reductions of IgG1 and IgG2a levels

decreased IgG1 level ( J:86697 )

decreased IgG2a level ( J:86697 )

decreased IgM level ( J:86697 )

• significantly reduced levels

abnormal T-helper 2 physiology ( J:86697 )

• defect indicated by low Il-4 levels and low IgF1 and IgE levels

abnormal interferon level ( J:86697 )

• Ifn-gamma levels slightly increased

abnormal interleukin secretion ( J:86697 )

• Il-2 production reduced

• Il-4 production greatly impaired

homeostasis/metabolism

abnormal interferon level ( J:86697 )

• Ifn-gamma levels slightly increased