Phenotypes Associated with This Genotype

Genotype
MGI:2681718

• Allelic Composition: Rag1^tm1Fwa/Rag1^tm1Fwa
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

thymus hypoplasia ( J:86464 )

• reduced thymic cellularity

abnormal B cell differentiation ( J:86464 )

• transition from pro-B to pre-B modestly impaired

• reduced overall level of heavy chain VDJ rearrangements in pro-B cells

• order in which heavy chain VDJ rearrangements occur is frequently abnormal

abnormal T cell differentiation ( J:86464 )

• transition from pro-T to pre-T cells is impaired

increased double-negative T cell number ( J:86464 )

• high percentage of double negative pro-T cells, particularly CD25+CD44- (DN3)stage

• approximately normal distribution of double positive and single positive cells

decreased B cell number ( J:86464 )

• splenic B cells reduced about 50%

hematopoietic system

thymus hypoplasia ( J:86464 )

• reduced thymic cellularity

abnormal B cell differentiation ( J:86464 )

• transition from pro-B to pre-B modestly impaired

• reduced overall level of heavy chain VDJ rearrangements in pro-B cells

• order in which heavy chain VDJ rearrangements occur is frequently abnormal

abnormal T cell differentiation ( J:86464 )

• transition from pro-T to pre-T cells is impaired

increased double-negative T cell number ( J:86464 )

• high percentage of double negative pro-T cells, particularly CD25+CD44- (DN3)stage

• approximately normal distribution of double positive and single positive cells

decreased B cell number ( J:86464 )

• splenic B cells reduced about 50%

endocrine/exocrine glands

thymus hypoplasia ( J:86464 )

• reduced thymic cellularity