Phenotypes Associated with This Genotype

Genotype
MGI:2680269

• Allelic Composition: Erbb4^tm1Fej/Erbb4^tm1Fej; Tg(Wap-cre)11738Mam/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal mammary gland development ( J:86319 )

♀ • lobuloalveolar development retarded

abnormal mammary gland growth during lactation ( J:86319 )

♀ • by day 3 of lactation, extensive regression occuring, complete by day 10

♀ • epithelial proliferation declines in first day of lactation

♀ • early development of alveolar secretory epithelium normal, terminal stages fail

abnormal lactation ( J:86319 )

♀ • 83% of litters born to biparous mothers die within 2 days of birth but survive when cross fostered to normal mothers

♀ • failure of activated STAT5 to localize to nucleus

♀ • STAT5 lacks detectable tyrosine phosphorylation

♀ • STAT5 dependent proteins reduced

integument

abnormal mammary gland development ( J:86319 )

♀ • lobuloalveolar development retarded

abnormal mammary gland growth during lactation ( J:86319 )

♀ • by day 3 of lactation, extensive regression occuring, complete by day 10

♀ • epithelial proliferation declines in first day of lactation

♀ • early development of alveolar secretory epithelium normal, terminal stages fail

abnormal lactation ( J:86319 )

♀ • 83% of litters born to biparous mothers die within 2 days of birth but survive when cross fostered to normal mothers

♀ • failure of activated STAT5 to localize to nucleus

♀ • STAT5 lacks detectable tyrosine phosphorylation

♀ • STAT5 dependent proteins reduced