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Phenotypes Associated with This Genotype
Genotype
MGI:2679917
Allelic
Composition
Foxj1tm1Slb/Foxj1tm1Slb
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxj1tm1Slb mutation (0 available); any Foxj1 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most die at birth to P3, though some survived as long as P12-P40 (J:73616)
• most die at birth to P3, though some survived as long as P12-P40 (J:73616)
• mice do not survive beyond P7 (J:174694)
• mice do not survive beyond P7 (J:174694)

embryogenesis
• completely immotile nodal cilia (J:182741)
• completely immotile nodal cilia (J:182741)
• appear slightly smaller compared to wild-type controls (J:182741)
• appear slightly smaller compared to wild-type controls (J:182741)
• position of cilia emergence is randomized rather than polarized towards the posterior end of the nodal cells (J:182741)
• position of cilia emergence is randomized rather than polarized towards the posterior end of the nodal cells (J:182741)
• severe reduction in length in both mid and late head fold stage embryos (J:182741)
• severe reduction in length in both mid and late head fold stage embryos (J:182741)

nervous system
• at P21, multiple brain regions and the olfactory bulb exhibit growth defects compared to in wild-type mice (J:154976)
• at P21, multiple brain regions and the olfactory bulb exhibit growth defects compared to in wild-type mice (J:154976)
• mice exhibit growth retardation in the olfactory bulb (J:154976)
• mice exhibit growth retardation in the olfactory bulb (J:154976)
• those that survive to P7, develop a hydrocephalic head shape (J:73616)
• those that survive to P7, develop a hydrocephalic head shape (J:73616)
• cerebral ventricles lack cilia (J:154976)
• cerebral ventricles lack cilia (J:154976)
• at P21, the ependymal layer organization is disrupted and S100b+ ependymal cells are absent at P6 and P21 (J:154976)
• at P21, the ependymal layer organization is disrupted and S100b+ ependymal cells are absent at P6 and P21 (J:154976)
• absence of classic motile type cilia with a 9 + 2 microtubule ultrastructure in the brain (J:73616)
• in contrast, normal embryonic node cilia are present at E7.5 to E7.7 (J:73616)
• absence of classic motile type cilia with a 9 + 2 microtubule ultrastructure in the brain (J:73616)
• in contrast, normal embryonic node cilia are present at E7.5 to E7.7 (J:73616)
• in mice that survived past P7 (J:73616)
• in mice that survived past P7 (J:73616)
• at P21, the volume of the olfactory bulb is reduced compared to in wild-type mice (J:154976)
• at P21, the volume of the olfactory bulb is reduced compared to in wild-type mice (J:154976)
• at P21, the surface of the subventricular zone lacks cilia unlike in wild-type mice (J:154976)
• at P21, the surface of the subventricular zone lacks cilia unlike in wild-type mice (J:154976)
• on the ventricular surface (J:154976)
• on the ventricular surface (J:154976)

cardiovascular system
• abnormalities of the great vessels of the heart including transposition (J:73616)
• abnormalities of the great vessels of the heart including transposition (J:73616)

growth/size/body
• approximately half the homozygous mice exhibit heterotaxia or dextrocarida or both (J:73616)
• approximately half the homozygous mice exhibit heterotaxia or dextrocarida or both (J:73616)

respiratory system
• absence of classic motile type cilia with a 9 + 2 microtubule ultrastructure in the airway epithelial cells (J:73616)
• absence of classic motile type cilia with a 9 + 2 microtubule ultrastructure in the airway epithelial cells (J:73616)

reproductive system
• absence of classic motile type cilia with a 9 + 2 microtubule ultrastructure in the oviduct epithelial cells (J:73616)
• absence of classic motile type cilia with a 9 + 2 microtubule ultrastructure in the oviduct epithelial cells (J:73616)

cellular
• absence of classic motile type cilia with a 9 + 2 microtubule ultrastructure in the brain (J:73616)
• in contrast, normal embryonic node cilia are present at E7.5 to E7.7 (J:73616)
• absence of classic motile type cilia with a 9 + 2 microtubule ultrastructure in the brain (J:73616)
• in contrast, normal embryonic node cilia are present at E7.5 to E7.7 (J:73616)
• absence of classic motile type cilia with a 9 + 2 microtubule ultrastructure in the oviduct epithelial cells (J:73616)
• absence of classic motile type cilia with a 9 + 2 microtubule ultrastructure in the oviduct epithelial cells (J:73616)
• absence of classic motile type cilia with a 9 + 2 microtubule ultrastructure in the airway epithelial cells (J:73616)
• absence of classic motile type cilia with a 9 + 2 microtubule ultrastructure in the airway epithelial cells (J:73616)
• position of cilia emergence is randomized rather than polarized towards the posterior end of the nodal cells (J:182741)
• position of cilia emergence is randomized rather than polarized towards the posterior end of the nodal cells (J:182741)
• severe reduction in length in both mid and late head fold stage embryos (J:182741)
• severe reduction in length in both mid and late head fold stage embryos (J:182741)
• completely immotile nodal cilia (J:182741)
• completely immotile nodal cilia (J:182741)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory